Microdosimetry applied to nanosecond pulsed electric fields: a comparison on a single cell between real and ideal...

A microdosimetric analysis using ideal and real pulses was carried out in this paper. To perform this goal, authors employed an algorithm developed recently for nsPEF based on Laplace's equation and able to take into account cell compartment dispersivity. A comparison between biphasic real and ideal waveforms was carried out. The ideal pulse induced the highest pore density efficiency, hence evidencing that a device optimization to avoid waveform degradation and losses has a fundamental impact on the performances of the delivered pulses at the single cell level.