Related Experiment Video
Updated: May 25, 2026
Modified Experimental Conditions for Noise-Induced Hearing Loss in Mice and Assessment of Hearing Function and Outer Hair Cell Damage
Published on: February 10, 2023
[Study of protective effects on noise-induced hearing loss using N-acetyl-cysteine]
Zhenmin Ge1, Shu Ma, Xiaoqing Jia
1Department of Otorhinolaryngology, the 404th Hospital of PLA, Weihai, 264200, China. gezmin@163.com
Objective:
To evaluate the protective effects of oral administration of N-acetyl-cysteine (NAC) on noise-induced hearing loss.
Method:
Three hundred sixty three volunteers were recruited and randomly divided into two groups: experimental group (n=223) and control group (n=140). The subjects had received oral administration of NAC in the experimental group and placebo in the control group before noise exposure. The routine audiometric evaluation and ABR testing were performed and recorded pre- and post-noise exposure. The statistical analysis was carried out on the data obtained from two groups with SPSS 11.0.
Result:
The hearings of all the participatory were changed after noise exposure, but there were statistically significant differences between two groups.
Conclusion:
The protective effects of NAC were prominent on the noise-induced hearing loss.
