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14:34
A Bilingual Computational Workflow for Identifying Potential PLK1 Inhibitors in American Sign Language and English
Published on: April 3, 2026
Discovery and structural insight of a highly selective protein kinase inhibitor hit through click chemistry
Guoxian Gu1, Huihui Wang, Pi Liu
1College of Pharmacy and Tianjin Key Laboratory of Molecular Research, State, Nankai University, Tianjin, 300071, PR China.
Chemical Communications (Cambridge, England)
|February 9, 2012
Abstract:
Novel bisaryl maleimide derivatives to mimic natural kinase inhibitors were prepared through click chemistry. A highly selective hit was discovered in a 124-kinase-assay, and docking studies revealed a π-π stacking interaction with the Phe67 at the P-loop of GSK-3β kinase.
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