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Modified-Release Drug Delivery Systems: Site-Targeted01:24

Modified-Release Drug Delivery Systems: Site-Targeted

Site-targeted drug delivery systems enhance therapeutic efficacy while minimizing systemic toxicity and treatment costs. Unlike conventional methods, these systems ensure precise drug delivery, improving bioavailability and reducing side effects. Targeted drug delivery is classified into three levels. First-order targeting directs drugs to the capillary beds of specific organs or tissues. Second-order targets specific cell types, such as tumor cells, using receptor-mediated interactions.
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Targeted Cancer Therapies

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Targeted therapy for cancer using pH-responsive nanocarrier systems.

Somkamon Manchun1, Crispin R Dass, Pornsak Sriamornsak

  • 1Department of Pharmaceutical Technology, Faculty of Pharmacy, Silpakorn University, Nakhon Pathom 73000, Thailand.

Life Sciences
|February 14, 2012
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Summary

pH-responsive nanocarriers improve cancer chemotherapy by releasing drugs at tumor sites or inside cancer cells. This targeted drug delivery enhances treatment efficacy and reduces side effects.

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Oncology

Background:

  • Conventional chemotherapy often suffers from poor efficacy and significant systemic side effects.
  • Targeted drug delivery systems are crucial for improving cancer treatment outcomes.
  • Stimuli-responsive nanocarriers offer a promising strategy for localized drug release.

Purpose of the Study:

  • To investigate the potential of pH-responsive nanocarriers for enhanced cancer chemotherapy.
  • To explore drug release mechanisms triggered by tumor microenvironment acidity or intracellular compartments.
  • To evaluate the benefits of targeted drug delivery in improving therapeutic efficacy and reducing toxicity.

Main Methods:

  • Development of nanocarriers designed to respond to pH changes.
  • Utilizing the enhanced permeability and retention (EPR) effect for passive tumor targeting.
  • Investigating pH-controlled hydrolysis for drug release within acidic tumor extracellular fluids or endosomes/lysosomes.
  • Evaluating drug release kinetics and cellular uptake mechanisms.

Main Results:

  • pH-responsive nanocarriers accumulate in tumor tissues via the EPR effect.
  • Drug release is triggered by the acidic extracellular environment of tumors or by the acidic conditions within endosomes/lysosomes after cellular uptake.
  • This targeted release mechanism enhances drug concentration at the tumor site.
  • Reduced systemic drug exposure is observed, minimizing side effects.

Conclusions:

  • pH-responsive nanocarriers represent a viable strategy to improve cancer chemotherapy efficacy.
  • Targeted drug delivery via pH-responsive systems can overcome limitations of conventional chemotherapeutics.
  • This approach holds significant potential for developing more effective and safer cancer treatments.