ICM+: a versatile software for assessment of CSF dynamics.

Area of Science:

• Neurology
• Biomedical Engineering
• Medical Physics

Background:

• ICM+ software has been utilized since 2003 in the Cerebrospinal Fluid (CSF) Dynamics Laboratory.
• Over 1,500 diagnostic tests and monitoring sessions have been conducted using the software.

Purpose of the Study:

• To detail the diverse applications and configurations of ICM+ software in analyzing CSF dynamics.
• To highlight the software's role in investigating hydrocephalus and related conditions.
• To showcase the software's utility in shunt assessment and understanding complex neurophysiological parameters.

Main Methods:

• Utilized ICM+ for various configurations: ICP only, ICP and arterial blood pressure (ABP), ICP, ABP, and transcranial Doppler (TCD), ICP, ABP, and near-infrared spectroscopy (NIRS).
• Integrated CSF infusion studies with Positron Emission Tomography (PET) for cerebral blood flow (CBF) assessment.
• Employed the software for analyzing intracranial pressure (ICP), ABP, sagittal sinus pressure, and jugular vein pressure in specific patient groups.

Main Results:

• Facilitated identification of CSF dynamics models and analysis of compensatory reserve and B waves.
• Enabled assessment of pressure reactivity index, cerebral autoregulation, and cerebral blood volume fluctuations.
• Provided insights into hydrodynamic consequences of cerebral venous sinus stenosis and aided in shunt evaluation for underdrainage or overdrainage.

Conclusions:

• ICM+ software serves as a robust tool for the digital recording, analysis, and interpretation of complex neurophysiological data.
• The collected database of cases and signals is invaluable for advancing the investigation and understanding of hydrocephalus pathophysiology.
• The software supports the creation of virtual signals and analysis of their dependencies, enhancing diagnostic capabilities.