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Updated: May 24, 2026

Generation and Expansion of Primary, Malignant Pleural Mesothelioma Tumor Lines
Published on: April 21, 2022
Familial mesothelioma in first degree relatives
Alexandra M Kalogeraki1, Dimitrios J Tamiolakis, Eleni D Lagoudaki
1Department of Pathology-Cytopathology, Medical School, University of Crete, Heraklion, Crete, Greece. kalogerakimed@yahoo.gr
Abstract:
Occupational asbestos exposure is believed to be the primary etiologic link to mesothelioma. However, in the evaluation of familial mesothelioma, it is important to consider the possibility of household exposure to asbestos. In this study, we report a family in which the father with prolonged occupational asbestos exposure developed malignant pleural mesothelioma and his daughter 14 years later mesothelioma in situ with focally early invasion. Several reports of familial aggregations of mesothelioma strongly support that genetic factors in collaboration with environmental exposure may contribute etiologically to an as yet unknown fraction of occurrence of this disease.
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