Drug delivery properties of macroporous polystyrene solid foams
Cristina Canal1, Rosa Maria Aparicio, Alejandro Vilchez
1Pharmacy and Pharmaceutical Technology Dpt., R+D Associated Unit to CSIC, University of Barcelona (UB), Joan XXIII s/n, Barcelona, Spain.
Summary
New polymeric porous foams show potential as pharmaceutical dosage forms. These materials exhibit high porosity and enable controlled release of active ingredients like ketoprofen.
Area of Science:
- Materials Science
- Pharmaceutical Sciences
- Polymer Chemistry
Background:
- Polymeric porous foams are being explored as novel drug delivery systems.
- Developing materials with controlled porosity and surface properties is crucial for effective drug encapsulation and release.
Purpose of the Study:
- To evaluate polymeric porous foams as potential pharmaceutical dosage forms.
- To characterize the properties of these foams and their capacity for incorporating and releasing active pharmaceutical ingredients.
Main Methods:
- Polymeric porous foams were synthesized using the phase inversion temperature method with highly concentrated emulsions.
- Characterization included porosity, specific surface area, and surface topography analysis.
- Ketoprofen, a model lipophilic drug, was used to study drug incorporation and release kinetics.
Main Results:
- The synthesis method yielded solid foams with significant macropore volume and a rough surface topography.
- These structural features resulted in nearly superhydrophobic properties.
- Successful incorporation and delayed release of ketoprofen were demonstrated, with a short lag-time.
Conclusions:
- Polymeric porous foams are viable candidates for pharmaceutical dosage forms.
- The observed superhydrophobic nature and pore structure facilitate drug delivery applications.
- Controlled, delayed release of lipophilic drugs like ketoprofen can be achieved using these foam systems.
More Related Videos
Related Concept Videos
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:08Molecular Weight of Step-Growth Polymers
Step growth polymerization involves bi or multifunctional monomers. Bifunctional monomers react to form linear step growth polymers, whereas multifunctional monomers react to form non-linear or branched polymers.
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
As the step-growth polymerization involves step-wise condensation of monomers, the molecular weight also builds up eventually. Consequently, high molecular weight polymers are obtained at the late stages of the polymerization, where 99% of monomers have been consumed.
The extent of the...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:22Modified-Release Drug Delivery Systems: Drug Release Characteristics
Drug release from modified-release dosage forms is designed to achieve specific therapeutic effects by controlling the rate and extent of drug release. The classification of these drug release systems is based on key pharmacokinetic assumptions: drug disposition follows first-order kinetics, drug release is the rate-limiting step in absorption, and the released drug is rapidly and completely absorbed.There are four major models of drug release patterns. The first model is the slow zero-order...