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Related Concept Videos

Gross Anatomy of the Lungs01:17

Gross Anatomy of the Lungs

The lungs are a pair of vital organs connected to the trachea via the left and right bronchi. The base of these organs meets the dome-shaped muscle known as the diaphragm. Encased by the pleurae, the lungs contact the mediastinum. The right lung is shorter yet wider, and has a larger volume than the left lung. The left lung has an indentation known as the cardiac notch. The superior region of the lungs is referred to as the apex, whereas the base is the lower region near the diaphragm. The...
Anatomy of Respiratory System II: Lower Respiratory Tract01:31

Anatomy of Respiratory System II: Lower Respiratory Tract

The lower respiratory tract is anatomically composed of several vital structures, including the larynx, trachea, bronchial tree, alveoli, lungs, and pleurae. Each component has a specific function, and all are intricately connected to ensure efficient respiration.
The Larynx
It is located between the pharynx and the trachea, acts as a passageway for air, and hosts several critical structures, such as the epiglottis, vocal cords, and glottis. The epiglottis acts as a gateway, guiding food to the...
Muscles of the Thorax01:25

Muscles of the Thorax

The thorax muscles are central to the body's respiration and provide essential support and movement for the upper body. They are intricately designed to facilitate the complex breathing process while also contributing to the structural integrity and mobility of the chest and upper limbs.
The diaphragm is at the core of thoracic musculature, the primary muscle involved in breathing. This expansive, dome-shaped muscle marks the division between the thoracic and abdominal cavities. It originates...
Pleura of the Lungs01:13

Pleura of the Lungs

The lungs are nestled in a cavity, shielded by the pleura. The pleura, a form of serous membrane, wraps around each lung. This membrane arrangement consists of two layers: the visceral and parietal pleurae. The visceral pleura lines the surface of the lungIn contrast, the parietal pleura is the outer layer and contacts to the thoracic wall, the mediastinum, and the diaphragm. The hilum is the point of connection between the visceral and parietal layers. The space between the parietal and...
Mechanism of Breathing III: The Accessory Muscles01:21

Mechanism of Breathing III: The Accessory Muscles

The Role of Accessory Muscles in the Respiratory System
The respiratory system is a complex network that relies on primary respiratory muscles like the diaphragm, but also involves accessory muscles to enhance lung expansion and airflow during both inhalation and exhalation.
Enhancing Inhalation with Accessory Muscles:
Accessory muscles such as the sternocleidomastoid, scalene, intercostal, and abdominal muscles are crucial when additional respiratory effort is required, such as during deep...
Breathing01:05

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...

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Updated: May 24, 2026

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis
07:52

Implantation of Fibrin Gel on Mouse Lung to Study Lung-specific Angiogenesis

Published on: December 21, 2014

Matrikines and the lungs.

Janette K Burgess1, Markus Weckmann

  • 1Cell Biology, Woolcock Institute of Medical Research, Sydney, NSW, Australia. janette.burgess@sydney.edu.au

Pharmacology & Therapeutics
|February 28, 2012
PubMed
Summary
This summary is machine-generated.

Matrikines, fragments of extracellular matrix proteins, have unique biological roles in lung health and disease. These molecules, interacting with cell receptors like integrins, show therapeutic potential in clinical trials for lung conditions.

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Area of Science:

  • Pulmonary Medicine
  • Cell Biology
  • Biochemistry

Background:

  • The lung's extracellular matrix provides structural support and regulates cell behavior.
  • Matrikines are biologically active fragments of extracellular matrix proteins released by proteases.
  • These fragments have independent functions in lung physiology and pathology.

Purpose of the Study:

  • To review the current understanding of matrikines in lung health and disease.
  • To explore the roles of matrikines and their therapeutic potential.
  • To summarize matrikine interactions with cell surface receptors, including integrins.

Main Methods:

  • Literature review of matrikine function and therapeutic applications.
  • Analysis of matrikine roles in lung physiology and disease pathology.
  • Examination of matrikine interactions with cellular receptors and co-factors.

Main Results:

  • Matrikines possess independent biological activities, influencing lung cells.
  • Integrins are key receptors for matrikine signaling, with emerging roles for co-factors.
  • Matrikine-derived peptides demonstrate therapeutic potential, with some in clinical trials.

Conclusions:

  • Matrikines are significant mediators in lung health and disease.
  • Their roles in angiogenesis and inflammation suggest therapeutic applications.
  • Further research into matrikine-based therapies holds promise for lung disease treatment.