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[Study on the preparation of curcumin inclusion complex and its stability]
Zhen-Shen Gao1, Ying-Xiao Fu, Jian-Duo Wang
1College of Chemistry and Chemical Engineering, Linyi University, Linyi 276005, China. gaozhenshen@lyu.edu.cn
Objective:
To prepare the curcumin inclusion complex and study its stability.
Methods:
Beta-cyclodextrin (beta-CD) was chosen as inclusion material and orthogonal design method was used. UV-Vis spectrophotometer was used to determine the solubility and content of different samples. They were placed under conditions of light and the solution containing Fe(3+) to determine their stability.
Results:
The optimum preparation procedure were : curcumin and beta-cyclodextrin feed molar ratio of 1: 1, the concentration of ethanol was 40%, 40 degrees C inclusion temperature and 1 h reaction time.
Conclusion:
Inclusion complex prepared under eptimal condition is stable.
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