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Related Concept Videos

Cancer02:18

Cancer

Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
Cancer-Critical Genes I: Proto-oncogenes01:33

Cancer-Critical Genes I: Proto-oncogenes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
What is Cancer?02:12

What is Cancer?

Cells and tissues must meticulously coordinate their activities for the normal functioning of the human body. Therefore, they exhibit socially responsible behavior - resting, growing, dividing, differentiating, or dying - for the organism’s benefit. Cancer arises when cells divide uncontrollably and invade other tissues or organs.
Although people have known about cancer for centuries, it was only in 1761 that Giovanni Morgagni of Padua performed a detailed autopsy of patients who died from...

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Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line
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Published on: April 11, 2025

FGF19 and cancer.

Benjamin C Lin1, Luc R Desnoyers

  • 1Oncology Biomarker Development/Pharmacodynamic Biomarkers, Genentech, Inc., South San Francisco, CA, USA.

Advances in Experimental Medicine and Biology
|March 8, 2012
PubMed
Summary
This summary is machine-generated.

Fibroblast growth factor (FGF) signaling is crucial for development but its deregulation drives cancer. The FGF19-FGFR4 pathway is implicated in various cancers, including liver cancer.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Developmental Biology

Background:

  • Fibroblast growth factors (FGFs) and their receptors (FGFRs) regulate essential physiological and developmental processes.
  • Aberrant FGF-FGFR signaling is frequently observed in tumor development and progression.
  • The FGF19-FGFR4 signaling axis is specifically implicated in the pathogenesis of several cancers.

Purpose of the Study:

  • To review recent advancements in understanding the molecular mechanisms of FGF19 action.
  • To explore the role of the FGF19-FGFR4 axis in cancer development and progression.

Main Methods:

  • Literature review of recent research on FGF19 and FGFR4 signaling pathways.
  • Analysis of studies investigating the involvement of FGF19-FGFR4 in various cancer types.
  • Focus on molecular mechanisms underlying FGF19-mediated oncogenesis.

Main Results:

  • FGF19 signaling plays a significant role in cellular proliferation, survival, and migration.
  • FGFR4 activation by FGF19 contributes to tumor growth and metastasis in preclinical models.
  • Evidence suggests potential clinical relevance in human cancers, particularly hepatocellular carcinoma.

Conclusions:

  • The FGF19-FGFR4 pathway represents a promising therapeutic target for specific cancers.
  • Further research into the intricate molecular mechanisms is warranted for targeted therapeutic development.
  • Understanding FGF19-FGFR4 dysregulation is key to developing novel anti-cancer strategies.