Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:10

Transcription

Overview
Transcription is the process of synthesizing RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in the proper synthesis of messenger RNA (mRNA). Regulation of transcription is responsible for the differentiation of all the different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds...
Transcription01:17

Transcription

Transcription is the synthesis of RNA from a DNA sequence by RNA polymerase. It is the first step in producing a protein from a gene sequence. Additionally, many other proteins and regulatory sequences are involved in correctly synthesizing messenger RNA (mRNA). Transcriptional regulation is responsible for the differentiation of different types of cells and often for the proper cellular response to environmental signals.
Transcription Can Produce Different Kinds of RNA Molecules
In eukaryotes,...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Cell autonomous inflammation in VEXAS is mediated by cGAS-STING.

bioRxiv : the preprint server for biology·2026
Same author

An integrated RNA-centric imaging and omics approach reveals distinct properties and composition of neuronal RNA granules.

bioRxiv : the preprint server for biology·2026
Same author

RNA-binding proteins in the mouse lens: Functional classifications, expression profiling, and interaction studies of Carhsp1 with crystallin mRNAs.

Developmental biology·2026
Same author

A series of spontaneously blinking dyes for super-resolution microscopy.

Nature methods·2026
Same author

3D Chromosome Remodeling in B-cell Development and Acute Lymphoblastic Leukemia.

Blood cancer discovery·2026
Same author

A platform for analyzing translational control by RBPs at single-mRNA resolution in cells.

Biophysics and physicobiology·2026
Same journal

Publisher Correction: Collagen VI is a fibrosis-associated signal disrupting muscle regeneration across distinct human myopathies.

EMBO reports·2026
Same journal

Food for thought : The role of life cycle thinking in sustainable food system transitions.

EMBO reports·2026
Same journal

AURORA A interacts with DICER and SETD2 to promote S-phase progression.

EMBO reports·2026
Same journal

A distinct E dimer epitope underlies selective recognition by a protective human West Nile virus antibody.

EMBO reports·2026
Same journal

The big picture : Parasites, People and the Path to Ending Schistosomiasis.

EMBO reports·2026
Same journal

C-terminal lysine residues localise NLRP10 at lipid droplets and govern NLRP10 oligomer formation.

EMBO reports·2026
See all related articles

Related Experiment Video

Updated: May 24, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Transcription goes digital.

Timothée Lionnet1, Robert H Singer

  • 1Department of Anatomy & Structural Biology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

EMBO Reports
|March 14, 2012
PubMed
Summary
This summary is machine-generated.

Single-cell transcription shows high variability over time and between cells. This review explores techniques, models, and mechanisms driving these dynamic gene expression patterns for cell survival.

More Related Videos

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
10:46

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

Published on: October 18, 2022

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

Related Experiment Videos

Last Updated: May 24, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
09:26

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins
10:46

Gene Digital Circuits Based on CRISPR-Cas Systems and Anti-CRISPR Proteins

Published on: October 18, 2022

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR
09:16

Detection of a CDH1 Rare Transcript Variant in Fresh-frozen Gastric Cancer Tissues by Chip-based Digital PCR

Published on: February 5, 2018

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Genetics

Background:

  • Transcription is crucial for cellular response and survival.
  • Recent microscopy allows monitoring of single-gene transcription in individual cells.
  • Observed high cell-to-cell variability and rapid temporal changes in transcriptional activity.

Purpose of the Study:

  • To review techniques for investigating single-gene transcription.
  • To introduce quantitative modeling tools for transcription analysis.
  • To discuss mechanisms of transcription and their role in gene expression regulation.

Main Methods:

  • Advanced microscopy techniques for single-gene monitoring.
  • Quantitative modeling approaches.
  • Review of existing literature on transcription mechanisms.

Main Results:

  • Transcription exhibits significant heterogeneity across individual cells.
  • Transcriptional activity fluctuates dynamically over short timescales (minutes).
  • The underlying mechanisms involving chromatin, transcription machinery, and signaling are complex and not fully understood.

Conclusions:

  • Understanding single-cell transcription dynamics is key to gene expression regulation.
  • Further research is needed to elucidate the interplay of chromatin, machinery, and signaling.
  • This knowledge is vital for understanding cell fitness and survival strategies.