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![Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F2755.jpg&w=3840&q=50)
08:33
Microwave-assisted One-pot Synthesis of N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB)
Published on: June 28, 2011
N-(2-Chloro-4-methyl-phen-yl)succinamic acid
Acta Crystallographica. Section E, Structure Reports Online
|March 14, 2012
Summary
This study details the crystal structure of a novel chloro-substituted organic compound. Molecular analysis reveals specific twists and hydrogen bonding patterns, forming dimers and ribbons in its solid state.
Area of Science:
- Crystallography
- Organic Chemistry
- Molecular Structure
Background:
- Understanding molecular conformation and intermolecular interactions is crucial in organic chemistry.
- Crystal structure analysis provides detailed insights into molecular arrangement and bonding.
Purpose of the Study:
- To elucidate the crystal structure of the title compound, C(11)H(12)ClNO(3).
- To investigate the conformational properties and hydrogen bonding network within the crystal lattice.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of bond lengths, bond angles, and intermolecular interactions (hydrogen bonding).
Main Results:
- The N-C=O fragment exhibits a significant twist of 48.39° relative to the benzene ring.
- Carboxylic acid groups form centrosymmetric dimers via O-H⋯O hydrogen bonds.
- These dimers are further linked by N-H⋯O hydrogen bonds into extended ribbons along the a axis.
Conclusions:
- The study provides a detailed molecular and supramolecular description of C(11)H(12)ClNO(3).
- The observed hydrogen bonding patterns dictate the formation of dimers and ribbons, influencing the compound's solid-state architecture.
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