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Updated: May 24, 2026

Innovative Adipose Tissue Fractionation for Transforming Fat into Specialized Components
Published on: July 11, 2025
Autologous fat grafting to the lower one-third of the face
Stephen Metzinger1, James Parrish, Aldo Guerra
1Department of Plastic Surgery, Aesthetic Surgical Associates, Metairie, Louisiana, USA.
Abstract:
Volume loss contributes as much to the aging appearance of the face as sagging and rhytids. This occurs in the nasolabial and labiomental creases, as well as the lips, mandibular ramus, and the prejowl sulcus. Treatment of these areas with autogenous fat has yielded results that are generally good, but often of brief duration. To obtain the best results, trauma to the transplanted adipocytes must be avoided through meticulous attention to the details of technique. Observed complications are usually minor. Despite variability in the duration of effect, the fact that autogenous fat is relatively inexpensive and readily available makes it a viable alternative for facial volume replacement.

