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Oxidative damage in chronic heart failure: protection by captopril through free radical scavenging?
M Chopra1, J McMurray, J McLay
1Dept. of Medicine, Clinical Pharmacology, Strathclyde University, Glasgow, Scotland.
Advances in Experimental Medicine and Biology
|January 1, 1990
Abstract:
The pathogenesis of heart failure is not yet fully understood. In animal models there is some evidence to suggest a role for free radicals (FRs). We have investigated malondialdehyde - LM in plasma of patients with heart failure and found it to be raised when compared to controls. We present data to show that Captopril, a drug with an ACE inhibitory effect is a FR scavenger both in vitro and ex-vivo in patients with heart failure.