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Updated: May 23, 2026
Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
Published on: March 16, 2018
Effects of amikacin on maturation of the auditory analyzer in rabbits
I N D'yakonova1, I V Rakhmanova, A M Tikhomirov
1Research Laboratory of Clinical and Experimental Pediatric Otorhinolaryngology, Russian State Medical University, Ministry of Health Care and Social Development of the Russian Federation, Moscow, Russia.
Abstract:
We studied the dynamics of maturation of the hearing function by records of short-term latent brainstem evoked potentials and the effect of amikacin on maturation of the hearing function. The peripheral compartment of the auditory analyzer matures sooner than the central structures. Amikacin in therapeutic doses exhibited an ototoxic effect on the peripheral compartment of the auditory analyzer without impairing its central structures.
