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Updated: May 23, 2026

DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation
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DNA-Tethered RNA Polymerase for Programmable In vitro Transcription and Molecular Computation

Published on: December 29, 2021

Highly parallel translation of DNA sequences into small molecules

Rebecca M Weisinger1, S Jarrett Wrenn, Pehr B Harbury

  • 1Department of Chemistry, Stanford University, Stanford, California, United States of America.

Plos One
|April 6, 2012
PubMed
Summary

Researchers created large small-molecule libraries for drug discovery using DNA-programmed chemistry. This method enables the efficient synthesis of diverse small molecules with desirable drug-like properties for in vitro evolution.

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