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Toxicology and biocompatibility considerations in the evaluation of polymeric materials for biomedical applications
C T Laurencin1, H M Pierre-Jacques, R Langer
1Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge.
Clinics in Laboratory Medicine
|September 1, 1990
Abstract:
It is necessary to determine the safety of polymeric materials through laboratory and animal testing before biomedical use can become more widespread. This article describes many of the methods used in analyzing the toxicology and biocompatibility of potentially important biomedical polymers. The study method used in the development of an important new class of polymeric materials for human use, the poly(anhydrides), is presented from laboratory bench to human clinical trials.