Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Gap Junctions01:27

Gap Junctions

The cytoplasm of adjacent animal cells can exchange small molecules, ions, and secondary messengers via the communication channels which form the gap junctions. These junctions comprise a few hundred to thousands of molecular channels, each made of two halves, called the connexon hemichannel. A connexon is a hexamer of six transmembrane connexin proteins, which assemble radially, thus forming a pore or channel in the center. One connexon hemichannel docks with a corresponding connexon on the...
Gap Junctions01:37

Gap Junctions

Multicellular organisms employ a variety of ways for cells to communicate with each other. Gap junctions are specialized proteins that form pores between neighboring cells in animals, connecting the cytoplasm between the two, and allowing for the exchange of molecules and ions. They are found in a wide range of invertebrate and vertebrate species, mediate numerous functions including cell differentiation and development, and are associated with numerous human diseases, including cardiac and...
Type II Diabetes II: Pathophysiology01:24

Type II Diabetes II: Pathophysiology

PathophysiologyType 2 diabetes mellitus (T2DM ) is a chronic metabolic disorder characterized by insulin resistance and progressive pancreatic β-cell dysfunction, leading to impaired glucose homeostasis. It results from interactions among genetic predisposition, environmental factors, and metabolic stressors, such as overnutrition and a sedentary lifestyle.Insulin Resistance and Glucose DysregulationEarly T2DM involves insulin resistance in skeletal muscle, adipose tissue, and the liver.
Complications of Diabetes Mellitus01:22

Complications of Diabetes Mellitus

Diabetes mellitus is a chronic metabolic disorder characterized by persistent hyperglycemia due to insulin deficiency, resistance, or both. Prolonged hyperglycemia disrupts metabolic homeostasis and leads to acute and chronic complications.Acute ComplicationsAcute complications result from sudden metabolic imbalance.Diabetic ketoacidosis (DKA) mainly appears in type 1 diabetes but may also develop in type 2 diabetes, particularly under extreme stress. It arises from severe insulin deficiency,...
Pathophysiology of Diabetes01:20

Pathophysiology of Diabetes

Diabetes mellitus is a chronic metabolic disorder characterized by hyperglycemia. The four categories of diabetes are type 1 diabetes, type 2 diabetes, other specific types of diabetes, and gestational diabetes.
Type 1 diabetes is characterized by autoimmune-mediated destruction of pancreatic β cells, with environmental factors potentially triggering this process in genetically susceptible individuals. Despite many not having a family history, certain genes increase susceptibility, suggesting a...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

International practice patterns and perceptions of pressurised intraperitoneal aerosol chemotherapy for management of gastric cancer: A global clinician survey.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026
Same author

<i>Enterococcus faecium</i> colonization and persistence in a model of diabetic wound infection.

Infection and immunity·2026
Same author

Discovery of APO-50815, a potent WEE1 kinase inhibitor with exceptional efficacy against patient-derived colorectal cancer organoids.

European journal of medicinal chemistry·2026
Same author

Use of in vitro co-culture models to inform bacterial engineering for the treatment of solid tumours.

npj biomedical innovations·2026
Same author

Management of perioperative anaemia-five top tips.

The British journal of surgery·2026
Same author

Preoperative and postoperative anaemia in colorectal cancer surgery: Are we there yet?

Revista espanola de anestesiologia y reanimacion·2026
Same journal

Emerging Role of Statin Therapy in Preventing Anthracycline-Induced Cardiotoxicity.

Cardiology research and practice·2026
Same journal

Phenotypic Age Acceleration as a Mediator in Thyroid Hormone-Related Cardiovascular Risk Among the Elderly.

Cardiology research and practice·2026
Same journal

Applicability of Stress Cardiac Magnetic Resonance Imaging in Patients With Cardiac Implantable Devices: A Systematic Review.

Cardiology research and practice·2026
Same journal

Latest Management of Cardiac Sarcoidosis: A Comprehensive Review.

Cardiology research and practice·2026
Same journal

Predictive Equation for Peak Heart Rate and First Ventilatory Threshold Heart Rate in Patients With Coronary Heart Disease.

Cardiology research and practice·2026
Same journal

Electroacupuncture Protects Against Post-MI Heart Failure Through Autonomic Regulation and α7nAChR Activation.

Cardiology research and practice·2026
See all related articles

Related Experiment Video

Updated: May 22, 2026

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

Connexins and diabetes.

Josephine A Wright1, Toby Richards, David L Becker

  • 1Department of Vascular Surgery and Department of Cell and Developmental Biology, University College London Hospital, 74 Huntley Street, London NW1 2BU, UK.

Cardiology Research and Practice
|April 27, 2012
PubMed
Summary
This summary is machine-generated.

Connexins, proteins forming gap junctions, play a role in diabetes pathogenesis. Targeting these connexins offers a potential future strategy for treating diabetes and its complications.

More Related Videos

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

Related Experiment Videos

Last Updated: May 22, 2026

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy
08:47

Live Images of GLUT4 Protein Trafficking in Mouse Primary Hypothalamic Neurons Using Deconvolution Microscopy

Published on: December 7, 2017

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption
09:20

Perturbing Endothelial Biomechanics via Connexin 43 Structural Disruption

Published on: October 4, 2019

Area of Science:

  • Cell biology
  • Endocrinology
  • Molecular medicine

Background:

  • Cell-to-cell communication through gap junctions and connexon hemichannels is crucial in biological systems.
  • These structures, formed by connexins, are increasingly implicated in the pathogenesis of metabolic diseases like diabetes.
  • Understanding connexin roles is vital for developing novel therapeutic strategies.

Purpose of the Study:

  • To review current knowledge on connexins in the context of diabetes.
  • To elucidate the mechanisms by which connexins influence diabetes.
  • To examine the specific roles of individual connexins in various tissues affected by diabetes.

Main Methods:

  • Literature review and synthesis of existing research on connexins and diabetes.
  • Analysis of molecular mechanisms underlying connexin function in metabolic regulation.
  • Comparative examination of connexin expression and function across different tissues in diabetic models.

Main Results:

  • Gap junctional communication and connexon hemichannels are implicated in diabetes development.
  • Specific connexin proteins (e.g., Cx36, Cx43) show altered expression and function in diabetes.
  • Connexin dysfunction contributes to impaired insulin secretion, glucose metabolism, and tissue complications.

Conclusions:

  • Connexins are key players in diabetes pathogenesis, affecting multiple tissues and functions.
  • Modulating connexin activity presents a promising therapeutic avenue for diabetes and its complications.
  • Further research into connexin-targeted therapies could lead to significant advancements in diabetes treatment.