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Azepine synthesis from alkyl azide and propargylic ester via gold catalysis

Heng Liu1, Xin Li, Zili Chen

  • 1Department of Chemistry, Renmin University of China, Beijing 100872, PR China.

The Journal of Organic Chemistry
|May 16, 2012
PubMed

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Azide ions act as good nucleophiles and react with unhindered alkyl halides to form alkyl azides. Alkyl azides do not participate in further nucleophilic substitution reactions, thereby eliminating the chances of polyalkylated products. Alkyl azides are reduced by hydride-based reducing agents, like lithium aluminum...
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