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Leiden V factor and spastic cerebral palsy in Mexican children

María de la Luz Arenas-Sordo1, César Zavala-Hernández, César Casiano-Rosas

  • 1Genetics Department, National Institute of Rehabilitation, Mexico City, México. mlarenassordo@hotmail.com

Genetic Testing and Molecular Biomarkers
|May 17, 2012
PubMed

Insights

The Leiden mutation of factor V is not linked to spastic hemiparesis cerebral palsy (CP) in the Mexican mestizo population. Other perinatal factors like hypoxia and maternal infections are significant risks for CP.

Area of Science:

  • Neurology
  • Genetics
  • Perinatal Medicine

Background:

  • Cerebral palsy (CP) is a motor disorder resulting from early brain development interference.
  • The Leiden mutation of factor V has been proposed as a potential cause for spastic hemiparesis CP.

Purpose of the Study:

  • To investigate the association between the Leiden mutation of factor V and spastic hemiparesis CP in the Mexican mestizo population.
  • To identify other potential risk factors for CP in this demographic.

Main Methods:

  • A case-control study was conducted.
  • Included 94 patients with spastic hemiparesis CP, 120 controls, and their mothers.

Main Results:

  • The Leiden mutation was not found in any patients, mothers, or controls.
  • Significant risk factors identified include hypoxia (OR 7.189), smoking (OR 16.621), maternal infections (OR 7.040), shorter gestation (OR 0.866), and increased maternal age (OR 1.114).

Conclusions:

  • The Leiden mutation of factor V is not a significant risk factor for spastic hemiparesis CP in the Mexican mestizo population.
  • Perinatal factors such as hypoxia, smoking, maternal infections, prematurity, and maternal age are crucial risk factors for CP.
Abstract

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