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04:23
A Murine Model of Dengue Virus-induced Acute Viral Encephalitis-like Disease
Published on: April 28, 2019
Fulminant hepatic failure due to dengue
A Sedhain1, S Adhikari, S Regmi
1Department of Medicine, Chitwan Medical College, Bharatpur, Chitwan, Nepal. arunsedhain@gmail.com
Kathmandu University Medical Journal (KUMJ)
|May 22, 2012
Summary
Dengue Fever (DF) can cause acute liver failure, though rarely. This case highlights a young woman
Area of Science:
- Infectious Diseases
- Hepatology
- Critical Care Medicine
Background:
- Dengue Fever (DF) is infrequently recognized as a cause of acute liver failure (ALF).
- Limited case reports exist on ALF and encephalopathy in adult Dengue patients.
- A significant Dengue outbreak occurred in Chitwan in 2010.
Observation:
- A previously healthy 20-year-old female presented with fever, jaundice, and altered sensorium during a Dengue outbreak.
- Laboratory results indicated Dengue IgM positivity and severe acute liver injury.
- Biochemical markers showed markedly elevated liver enzymes (ALT, AST), high bilirubin, prolonged PT INR, and thrombocytopenia.
Findings:
- The patient was diagnosed with Dengue-associated Acute Liver Failure (ALF).
- Other potential causes of acute hepatic failure were excluded.
- Supportive care and platelet transfusion led to significant clinical and biochemical recovery.
Implications:
- This case underscores the importance of considering Dengue as a potential cause of ALF, even in non-endemic areas or during outbreaks.
- Early recognition and management of Dengue-induced ALF are crucial for patient outcomes.
- Further research into the mechanisms of Dengue hepatotoxicity is warranted.
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