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Updated: May 22, 2026

Simultaneous PET/MRI Imaging During Mouse Cerebral Hypoxia-ischemia
Published on: September 20, 2015
Significant head motion can cause either hypermetabolic or hypometabolic cerebral activity on 18F-FDG PET/CT
Linh Thuy Ho1, Vincent Ngo, Harvard Vuu
1PET Imaging Science Center, Division of Nuclear Medicine, Department of Radiology, Keck School of Medicine University of Southern California, Los Angeles, CA, USA. linhho@usc.edu
Abstract:
We report 2 separate cases with significant head motion causing apparent hypometabolic and hypermetabolic cerebral activity on FDG PET/CT. Case 1 is a 57-year-old man with facial numbness status post chemotherapy for mantle cell lymphoma. Restaging attenuation-corrected PET showed increased left frontal region activity, whereas nonattenuation-corrected PET demonstrated evidence of patient motion with normal physiologic left frontal cortical activity. Case 2 is a 78-year-old man with history of malignant melanoma. Attenuation-corrected PET/CT demonstrated diffusely decreased activity in the left cerebral hemisphere, whereas nonattenuation-corrected PET showed significant head motion with intact cortical activity.
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