Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Intralumenal Vesicles and Multivesicular Bodies

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...

Reticular Dermis

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...

Secondary Lymphoid Organs

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...

Eukaryotic Compartmentalization

Eukaryotic Compartmentalization

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...

Eukaryotic Compartmentalization

Eukaryotic Compartmentalization

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...

Eukaryotic Compartmentalizations

Eukaryotic Compartmentalizations

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

PREDICT Tool for Pregnancy-Associated CKD Progression.

Kidney international reports·2026

Same author

Vascular risk drives cognitive decline over 10 years in people aging with well-controlled HIV.

AIDS (London, England)·2026

Same author

Association between surgeon experience, level of supervision, and outcomes after hip fracture.

Bone & joint open·2026

Same author

Association Between Sex and Kidney Transplant Referral, Living Donor Contacts, Waitlisting and Kidney Transplant: A Population-Based Cohort Study.

Canadian journal of kidney health and disease·2026

Same author

A novel genetically distinct Amdoparvovirus in Sorex araneus in the United Kingdom highlights an unexplored ancestral link.

Virus research·2026

Same author

Estimating the seroprevalence of Mycobacterium bovis infection in a wild deer population in southwest England.

The Veterinary record·2026

Search research articles

Related Experiment Video

Updated: May 22, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Vimentin compartmentalization in discoid lupus.

Ana Maria Abreu-Velez¹, Graham Smith, Michael S Howard

¹Georgia Dermatopathology Associates, Atlanta, Georgia, USA.

North American Journal of Medical Sciences

|May 25, 2012

Summary

Discoid lupus erythematosus (DLE) involves immune deposits at the skin's basement membrane zone. This study reveals an additional dermal immune reorganization, suggesting a role in DLE's inflammatory process.

Keywords:

Vimentin autoantibodies discoid lupus erythematosus

More Related Videos

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Related Experiment Videos

Last Updated: May 22, 2026

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Skin Biopsy for Diagnosing Discoid Lupus Erythematosus

Published on: June 10, 2025

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus

Published on: May 16, 2025

Area of Science:

Dermatology
Immunopathology
Histopathology

Background:

Discoid lupus erythematosus (DLE) is a chronic inflammatory skin condition.
Lesions typically occur on sun-exposed areas like the face and scalp, causing scarring.

Observation:

A case study of a 46-year-old female patient evaluated for DLE.
Biopsies analyzed via H&E, IHC, and DIF revealed epidermal atrophy, follicular plugging, and dermal infiltrates.
Direct immunofluorescence showed IgG, IgM, fibrinogen, and C3 deposits at the basement membrane zone (BMZ) and sebaceous glands, plus IgA around dermal vessels.

Findings:

Immunohistochemistry confirmed vimentin compartmentalization around the BMZ of skin and sebaceous glands.
Similar immunoglobulin, complement, and fibrinogen patterns were observed as with DIF.
This indicates an orchestrated immunologic reorganization of the dermis beyond typical lupus band deposits.

Implications:

The study highlights the significance of dermal compartmentalization in inflammatory skin diseases like DLE.
This immunologic reorganization may play a crucial role in the pathophysiology of discoid lupus erythematosus.
Further research into these dermal changes could offer new insights into DLE treatment.