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Updated: May 22, 2026

Contrast-Enhanced Subharmonic Aided Pressure Estimation (SHAPE) Using Ultrasound Imaging with a Focus on Identifying Portal Hypertension
Published on: December 5, 2020
Endoscopic ultrasound: contrast enhancement
Masayuki Kitano1, Hiroki Sakamoto, Masatoshi Kudo
1Department of Gastroenterology and Hepatology, Kinki University School of Medicine, 377-2 Ohnohigashi, Osakasayama, 589-8511 Japan. m-kitano@med.kindai.ac.jp
Abstract:
The development of ultrasound contrast agents has allowed for the evaluation of vascularity in digestive organs by contrast-enhanced endoscopic ultrasonography (EUS). Contrast-enhanced Doppler EUS and contrast-enhanced harmonic EUS (CH-EUS) have improved characterization of pancreatic tumors, lymph nodes, and gastrointestinal submucosal tumors and compliment EUS fine-needle aspiration (FNA) in identifying malignant tumors. Moreover, CH-EUS can be used to identify the target for EUS-guided FNA by clearly depicting the outline of the lesions.
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