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Updated: May 21, 2026
07:08
Using Optical Coherence Tomography and Optokinetic Response As Structural and Functional Visual System Readouts in Mice and Rats
Published on: January 10, 2019
[Optical coherence tomography in neuro-ophthalmology].
T Garcia1, A Tourbah, É Setrouk
1Service d'ophtalmologie, hôpital Robert-Debré, CHU de Reims, avenue du Général-Koenig, 51092 Reims cedex, France.
Journal Francais D'Ophtalmologie
|June 9, 2012
Summary
Optical coherence tomography (OCT) quantifies retinal nerve fiber layer (RNFL) thickness for diagnosing anterior visual pathway diseases. OCT provides crucial data for neuro-ophthalmology, aiding in disease assessment and prognosis.
Area of Science:
- Neuro-ophthalmology
- Medical Imaging
Background:
- Optical coherence tomography (OCT) offers reproducible quantification of retinal nerve fiber layer (RNFL) thickness.
- OCT is a valuable tool for assessing diseases affecting the anterior visual pathway.
Purpose of the Study:
- To define the clinical utility of OCT in neuro-ophthalmology.
- To analyze the applications of RNFL thickness measurement using OCT.
Main Methods:
- Literature review using PubMed.
- Keywords: "optic neuropathy", "retinal nerve fiber layer thickness", "optical coherence tomography".
- Exclusion of glaucoma-related publications.
Main Results:
- RNFL thickness patterns vary with disease: progressive reduction (optic neuritis, chiasmal compression) or initial increase followed by reduction (papilledema, anterior ischemic optic neuropathy, Leber hereditary optic neuropathy).
Conclusions:
- OCT-derived RNFL data are essential for diagnosing, monitoring, and predicting outcomes in anterior visual pathway impairments.
- OCT is an important tool for routine neuro-ophthalmological assessments, similar to its role in macular disease.
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