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Updated: May 21, 2026

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
Published on: February 9, 2014
[Autophagy and its role in protective and damaging inflammatory response]
Krejsek Jan1, Hrncírová Lucia, Holmannová Drahomíra
1Univerzita Karlova v Praze, Lékarská fakulta v Hradci Králové, Ustav klinické imunologie a alergologie FN. krejsek@fnhk.cz
Abstract:
Autophagy is an integral part of cell strategy to overcome adverse living conditions. Moreover, autophagy participates in the protection of cytoplasm against invasion of the intracellular pathogenic bacteria. Abnormalities in the autophagy are participating on the inability of Crohn's disease patients to maintain gut microbiome homeostasis ultimating in the development of immunopathological reaction in these patients. Autophagy can enhance the survival of autoreactive T cells in multiple sclerosis patients thus contributing to the disease induction and progression.
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