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Updated: May 20, 2026
09:35
Measurement of Carotenoids in Perifovea using the Macular Pigment Reflectometer
Published on: January 29, 2020
Carotenoids and cardiovascular risk.
Paola Giordano1, Pietro Scicchitano, Manuela Locorotondo
1Department of Pediatry, University of Bari, Italy.
Current Pharmaceutical Design
|July 4, 2012
Summary
Carotenoids, found in fruits and vegetables, combat oxidative stress and reduce Low-Density Lipoprotein (LDL) oxidation. This review explores their role in preventing atherosclerosis progression and improving endothelial function.
Area of Science:
- Nutritional Biochemistry
- Cardiovascular Science
- Antioxidant Research
Background:
- Fruits and vegetables are rich sources of carotenoids, fat-soluble pigments crucial for human health.
- Carotenoids possess antioxidant properties due to their conjugated double bond structures.
- Oxidation of Low-Density Lipoprotein (LDL) is a key initial step in atherosclerosis, a major cause of cardiovascular events.
Purpose of the Study:
- To review the scientific literature on carotenoids' role in inhibiting atherosclerotic plaque initiation and progression.
- To assess the potential of dietary carotenoids in reducing LDL oxidation and improving endothelial function.
- To evaluate carotenoids as a dietary strategy against atherosclerosis.
Main Methods:
- Literature review of studies investigating carotenoids, oxidative stress, and atherosclerosis markers.
- Analysis of research linking carotenoid intake to reduced LDL oxidation.
- Examination of studies correlating carotenoid consumption with changes in Intima-Media Thickness (IMT) of the common carotid artery (CCA-IMT).
Main Results:
- Carotenoids scavenge reactive oxygen species (ROS), including singlet oxygen and free radicals.
- Reduced ROS levels are associated with a decreased atherosclerotic burden.
- Studies show a correlation between carotenoid intake and reduction in CCA-IMT, a marker of atherosclerosis.
Conclusions:
- Carotenoids play a significant role in mitigating atherosclerosis by reducing LDL oxidation and ROS levels.
- Dietary implementation of carotenoid-rich foods may be an effective strategy to prevent cardiovascular diseases.
- Further research should focus on carotenoids' impact on endothelial function and their therapeutic potential.
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