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Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes
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Measurement of In Vitro Integration Activity of HIV-1 Preintegration Complexes

Published on: February 22, 2017

HIV-1 assembly, budding, and maturation.

Wesley I Sundquist1, Hans-Georg Kräusslich

  • 1Department of Biochemistry, University of Utah School of Medicine, Salt Lake City, Utah, USA. wes@biochem.utah.edu

Cold Spring Harbor Perspectives in Medicine
|July 5, 2012
PubMed
Summary
This summary is machine-generated.

This review details human immunodeficiency virus type 1 (HIV-1) virion morphogenesis, covering assembly, budding, and maturation. These stages are orchestrated by the Gag polyprotein, crucial for HIV-1 replication and spread.

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Structure of HIV-1 Capsid Assemblies by Cryo-electron Microscopy and Iterative Helical Real-space Reconstruction

Published on: August 9, 2011

Area of Science:

  • Virology
  • Molecular Biology
  • Cell Biology

Background:

  • Retroviruses, including human immunodeficiency virus type 1 (HIV-1), possess the ability to assemble infectious virions.
  • Virion assembly, budding, and maturation are critical for viral spread and host infection.
  • The Gag polyprotein and its derivatives are central to these viral processes.

Purpose of the Study:

  • To provide a comprehensive review of the mechanisms governing HIV-1 virion morphogenesis.
  • To elucidate the distinct stages of assembly, budding, and maturation in HIV-1 lifecycle.
  • To highlight the pivotal role of the Gag polyprotein in coordinating these events.

Main Methods:

  • This study is a review of existing literature on HIV-1 virion morphogenesis.
  • It synthesizes current understanding of the molecular mechanisms involved.
  • Focuses on the stages of assembly, budding, and maturation.

Main Results:

  • HIV-1 virion morphogenesis involves three sequential stages: assembly, budding, and maturation.
  • The Gag polyprotein acts as a key orchestrator, directing virion formation and packaging.
  • Proteolytic processing of Gag products is essential for achieving infectious virions.

Conclusions:

  • Understanding HIV-1 morphogenesis is crucial for developing antiviral strategies.
  • The Gag polyprotein's function is central to viral replication and infectivity.
  • Further research into these stages can reveal new therapeutic targets.