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Related Concept Videos

Fertilization01:38

Fertilization

During fertilization, an egg and sperm cell fuse to create a new diploid structure. In humans, the process occurs once the egg has been released from the ovary, and travels into the fallopian tubes. The process requires several key steps: 1) sperm present in the genital tract must locate the egg; 2) once there, sperm need to release enzymes to help them burrow through the protective zona pellucida of the egg; and 3) the membranes of a single sperm cell and egg must fuse, with the sperm...
Spermatogenesis01:41

Spermatogenesis

Spermatogenesis is the process by which haploid sperm cells are produced in the male testes. It starts with stem cells located close to the outer rim of seminiferous tubules. These spermatogonial stem cells divide asymmetrically to give rise to additional stem cells (meaning that these structures “self-renew”), as well as sperm progenitors, called spermatocytes. Importantly, this method of asymmetric mitotic division maintains a population of spermatogonial stem cells in the male reproductive...

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Related Experiment Video

Updated: May 20, 2026

Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

[Can specialized sperm analysis predict fertilization ability?].

N Hakima1, N Sermondade, C Sifer

  • 1Service d'histologie-embryologie-cytogénétique-CECOS, hôpital Jean-Verdier, AP-HP, avenue du 14-Juillet, 93143 Bondy, France.

Gynecologie, Obstetrique & Fertilite
|July 6, 2012
PubMed
Summary
This summary is machine-generated.

Secondary sperm tests may predict fertilization failure in conventional in vitro fertilization (cIVF) for cases of idiopathic or pseudo-idiopathic infertility. These specialized tests help identify qualitative sperm defects when standard semen analysis is normal.

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Related Experiment Videos

Last Updated: May 20, 2026

Fluorimetric Techniques for the Assessment of Sperm Membranes
08:58

Fluorimetric Techniques for the Assessment of Sperm Membranes

Published on: November 28, 2018

Sperm Collection of Differential Quality Using Density Gradient Centrifugation
03:28

Sperm Collection of Differential Quality Using Density Gradient Centrifugation

Published on: November 29, 2018

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects
08:48

Flow Cytometric Analysis of Biomarkers for Detecting Human Sperm Functional Defects

Published on: April 21, 2022

Area of Science:

  • Reproductive Medicine
  • Andrology
  • Assisted Reproductive Technologies (ART)

Context:

  • Conventional in vitro fertilization (cIVF) success depends on sperm motility and fertilizing ability.
  • Fertilization failure can occur even with normal conventional sperm parameters, suggesting underlying qualitative sperm defects.
  • Idiopathic or pseudo-idiopathic infertility cases present diagnostic challenges for predicting cIVF outcomes.

Purpose:

  • To review and analyze existing literature on secondary sperm function tests.
  • To evaluate the predictive ability of these specialized sperm tests for fertilization rates in cIVF.
  • To identify tools for assessing sperm fertilizing capacity in unexplained infertility.

Summary:

  • This review examines secondary sperm function tests to predict fertilization success in cIVF.
  • Focus is placed on idiopathic and pseudo-idiopathic infertility where standard semen analysis is normal.
  • The literature is analyzed to determine the efficacy of specialized sperm tests in identifying fertilization potential.

Impact:

  • Aims to improve the selection of appropriate ART procedures for couples with unexplained infertility.
  • May lead to more accurate prognostication of cIVF success rates.
  • Could guide clinicians in choosing the most effective diagnostic and therapeutic strategies for male infertility.