[Microparticles, stem cells' new mechanism for tissue repair?]

Though stem cell transplantation has been confirmed to be useful in repairing aging and diseased tissues, the underlying mechanism remains elusive. In addition to soluble molecules, cells-derived membrane microparticles (MPs) are considered as new mediators served in cross-talk communication among cells. MPs are tiny membrane coated subcellular vesicles released by a variety of cell types including stem cells. MPs may interact with target cells through specific receptor-ligand interactions and transfering proteins, bioactive lipids, mRNA and miRNA. Composition and function of stem cells derived MPs are highlighted in recent years. Here, we give an overview of MPs'composition, vesiculation and liberation mechanism, roles involved in communication exchages, and research progress in stem cells derived MPs. The report here might provide some novel information to highlight the stem cells therapy.