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Updated: May 20, 2026
A Cell Free Assay System Estimating the Neutralizing Capacity of GM-CSF Antibody using Recombinant Soluble GM-CSF Receptor
Published on: June 27, 2011
Pharmacological properties of granulocytic colony-stimulating factor pegylated using electron beam synthesis
A M Dygai1, G N Zyuz'kov, V V Zhdanov
1Institute of Pharmacology, Siberian Division of the Russian Academy of Medical Sciences, Tomsk, Russia. mmu@pharm.tsu.ru
Abstract:
Granulocytic CSF pegylated using electron-beam synthesis nanotechnology exhibits pronounced granulomonocytopoiesis-stimulating and SC-mobilizing activity. More potent stimulation of committed precursors against the background of less pronounced activation of polypotent hemopoietic cells is a peculiarity of hemostimulating action of pegylated using electron-beam synthesis nanotechnology granulocytic CSF in comparison with its non-modified analog. The mobilizing effect of pegylated using electron-beam synthesis nanotechnology granulocytic CSF on early progenitor elements surpasses that of non-conjugated cytokine.
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