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Asthma I: Introduction01:28

Asthma I: Introduction

Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs01:25

Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs

Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
Allergic Reactions02:06

Allergic Reactions

Overview

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Related Experiment Video

Updated: May 20, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Polyphenols and their components in experimental allergic asthma.

M Joskova1, V Sadlonova, G Nosalova

  • 1Department of Pharmacology, Comenius University, Martin, Slovakia. joskova@jfmed.uniba.sk

Advances in Experimental Medicine and Biology
|July 28, 2012
PubMed
Summary

Natural polyphenols like Provinol and Flavin-7 show significant anti-inflammatory effects in experimental allergic asthma, unlike their individual components.

More Related Videos

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Related Experiment Videos

Last Updated: May 20, 2026

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
06:34

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma

Published on: June 4, 2017

Murine Model of Allergen Induced Asthma
08:05

Murine Model of Allergen Induced Asthma

Published on: May 14, 2012

Area of Science:

  • Immunology
  • Pharmacology
  • Natural Products Chemistry

Background:

  • Allergic asthma is a chronic inflammatory airway disease.
  • Polyphenolic compounds are plant-derived molecules with potential therapeutic properties.
  • Investigating natural compounds for asthma treatment is a key research area.

Purpose of the Study:

  • To evaluate the anti-inflammatory effects of polyphenolic compounds (Provinol, Flavin-7) and their components (quercetin, resveratrol) in a guinea pig model of allergic asthma.
  • To assess the impact on airway hyperresponsiveness and inflammatory cytokine levels.

Main Methods:

  • Experimental allergic asthma induced by ovalbumin sensitization in guinea pigs.
  • Assessment of airway reactivity using whole-body plethysmography.
  • In vitro study of tracheal smooth muscle reactivity to histamine and acetylcholine.
  • Measurement of interleukin-4 (IL-4) and interleukin-5 (IL-5) in bronchoalveolar lavage fluid.

Main Results:

  • Provinol and Flavin-7 demonstrated significant anti-inflammatory effects in the airways.
  • Individual components, quercetin and resveratrol, did not exhibit similar anti-inflammatory activity.
  • Cytokine levels (IL-4, IL-5) were modulated by the tested polyphenols.

Conclusions:

  • Polyphenolic compounds, as a whole, are more effective in treating airway inflammation in experimental asthma than their isolated components.
  • This suggests a synergistic or complementary action of multiple compounds within the natural extracts.
  • Further research into complex polyphenol formulations for asthma management is warranted.