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Cytomegalovirus bearing in children with sensorineural hearing losses

T Devdariani1, N Chibalashvili, M Tushishvili

  • 1Tbilisi State Medical University, Tbilisi, Georgia.

Georgian Medical News
|August 9, 2012
PubMed

Insights

Cytomegalovirus (CMV) infection is found in 93.3% of children with sensorineural hearing loss, which is twice the rate in healthy children. Early detection of CMV is crucial for effective hearing loss treatment.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Audiology

Background:

  • Sensorineural hearing loss (SNH) in children can have various causes, including congenital infections.
  • Cytomegalovirus (CMV) is a common viral infection that can be transmitted congenitally and may lead to long-term health issues.
  • Hearing impairment is a significant consequence of congenital CMV infection.

Purpose of the Study:

  • To investigate the prevalence of cytomegalovirus (CMV) in children diagnosed with sensorineural hearing loss (SNH).
  • To compare CMV infection rates between children with SNH and healthy children.
  • To highlight the importance of early CMV detection in managing hearing loss.

Main Methods:

  • A case-control study involving 15 children (3-6 years) with SNH and 30 age-matched healthy children.
  • CMV-specific IgG antibodies were quantified using the enzyme-linked immunosorbent assay (ELISA) in blood samples.
  • Auditory brainstem responses (ABRs) were used for objective hearing assessment in both groups.

Main Results:

  • CMV IgG antibodies were detected in 93.3% (14/15) of children with SNH.
  • CMV IgG antibodies were detected in 46.7% (14/30) of healthy children.
  • The difference in CMV prevalence between the groups was statistically significant (p=0.007), indicating a higher rate in children with hearing loss.

Conclusions:

  • CMV infection is significantly more prevalent in children with sensorineural hearing loss compared to their healthy peers.
  • Early identification of hearing loss and CMV status is essential for timely intervention.
  • Prompt assessment and treatment can improve outcomes for children affected by CMV-related hearing impairment.

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