Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Intralumenal Vesicles and Multivesicular Bodies01:38

Intralumenal Vesicles and Multivesicular Bodies

Intraluminal vesicles (ILVs) are small vesicles 50-80 nm in diameter formed during the maturation of early endosomes. A specialized endosome containing numerous ILVs is called a multivesicular body (MVB). ILVs contain internalized molecules such as antigens, nucleic acids, proteins, and metabolites. Some of these molecules are released from the MVBs inside exosomes and are transported to other cells. Other MVBs contain molecules that are retained in the ILVs and are later degraded within the...
Clathrin Coated Vesicles01:12

Clathrin Coated Vesicles

Clathrin-coated vesicles use endocytosis to transport receptors and lysosomal hydrolases from the Golgi to the lysosome in the late secretory pathway. Clathrin-mediated endocytosis was the first described endocytic process, and Clathrin-coated vesicles remain one of the most well-studied transport vesicles. The molecular machinery that generates clathrin-coated vesicles comprises over 50 proteins that precisely coordinate vesicle formation. Cell surface receptors concentrated in indented sites...
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
Diversity of Protists II01:27

Diversity of Protists II

Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
Eukaryotic Compartmentalizations01:46

Eukaryotic Compartmentalizations

One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
COP Coated Vesicles00:59

COP Coated Vesicles

Membrane-enclosed structures called vesicles transport proteins and lipids across the cell. The vesicles derive their cargo from the plasma membrane, Golgi, ER, or endosome. Coated vesicles are spherical, protein-coated carriers with a 50–100 nm diameter that mediate bidirectional transport between the ER and the Golgi. The distribution of proteins between the ER and Golgi complex is dynamic and is maintained by different coated vesicles. Their formation is driven by the assembly of different...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polypharmacology Browser PPB3: A Web-Based Deep Learning Tool for Target Prediction Using ChEMBL Data.

Journal of chemical information and modeling·2026
Same author

A novel polypeptide molecule attenuates atopic dermatitis by targeting CCR8-CCL1 axis.

International immunopharmacology·2025
Same author

Diversifying the triquinazine scaffold of a Janus kinase inhibitor.

RSC medicinal chemistry·2025
Same author

Modeling Binding Selectivity of Xylene Isomers in Resorcin[4]arene-Based Organo- and Metallo-Cavitands.

The Journal of organic chemistry·2025
Same author

Selective Aliphatic Aldimine Formation and Stabilization by a Hydrophobic Capsule in Water.

Journal of the American Chemical Society·2025
Same author

Recent Applications of Pillararene-Inspired Water-Soluble Hosts.

Chemistry (Weinheim an der Bergstrasse, Germany)·2025
Same journal

An intrinsically stretchable nanowire-based sensing patch for wearable analysis of sweat chloride ion composition.

Chemical communications (Cambridge, England)·2026
Same journal

A sterically rigid-flexible balanced NHC-Pd precatalyst for room-temperature solvent-free C-N coupling of benzocyclic amines.

Chemical communications (Cambridge, England)·2026
Same journal

Portable fluorescent conjugated microporous polymer sensor coupled with a smartphone for on-site Fe<sup>3+</sup> detection in water.

Chemical communications (Cambridge, England)·2026
Same journal

Accelerated discovery of NO<sub>3</sub>RR single-atom catalysts <i>via</i> high-throughput DFT and machine learning.

Chemical communications (Cambridge, England)·2026
Same journal

Wafer-scale robust graphene electronics under industrial processing conditions.

Chemical communications (Cambridge, England)·2026
Same journal

Subnanoscale IrW oxide anodes: breaking immiscibility for high activity and durability in water electrolysis.

Chemical communications (Cambridge, England)·2026
See all related articles

Related Experiment Video

Updated: May 19, 2026

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

Deep cavitand vesicles--multicompartmental hosts.

Jens Kubitschke1, Sacha Javor, Julius Rebek

  • 1Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.

Chemical Communications (Cambridge, England)
|August 10, 2012
PubMed
Summary
This summary is machine-generated.

Researchers synthesized water-based vesicles from deep cavitands. These versatile vesicles can host small molecules, hydrophobic guests, and hydrophilic molecules within distinct compartments.

More Related Videos

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography
07:00

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Published on: August 5, 2021

Bacterial Cell Culture at the Single-cell Level Inside Giant Vesicles
07:33

Bacterial Cell Culture at the Single-cell Level Inside Giant Vesicles

Published on: April 30, 2019

Related Experiment Videos

Last Updated: May 19, 2026

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus
09:04

Isolation And Dendritic Cell-Uptake of Small Extracellular Vesicles from Echinococcus granulosus

Published on: March 28, 2025

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography
07:00

Preparing Lamellae from Vitreous Biological Samples Using a Dual-Beam Scanning Electron Microscope for Cryo-Electron Tomography

Published on: August 5, 2021

Bacterial Cell Culture at the Single-cell Level Inside Giant Vesicles
07:33

Bacterial Cell Culture at the Single-cell Level Inside Giant Vesicles

Published on: April 30, 2019

Area of Science:

  • Supramolecular Chemistry
  • Materials Science
  • Nanotechnology

Background:

  • Cavitands are macrocyclic molecules known for their unique binding properties.
  • Vesicles are self-assembled structures with potential applications in encapsulation and delivery.
  • Controlling guest encapsulation within self-assembled systems is a key challenge.

Purpose of the Study:

  • To synthesize and characterize novel vesicles formed from deep cavitands in aqueous solutions.
  • To investigate the ability of these cavitand-based vesicles to host multiple types of guests simultaneously.
  • To explore the potential of these structures as versatile host systems.

Main Methods:

  • Self-assembly of deep cavitands in water to form vesicular structures.
  • Characterization of vesicle morphology and stability using techniques like dynamic light scattering and microscopy.
  • Guest binding studies to assess the affinity and capacity for different guest molecules (small, hydrophobic, hydrophilic).

Main Results:

  • Successful synthesis of stable vesicles from deep cavitands in water.
  • Demonstration of selective guest encapsulation: cavitands bind small molecules, the bilayer hosts hydrophobic guests, and the inner aqueous core accommodates hydrophilic molecules.
  • Evidence of multi-component guest loading within a single vesicle system.

Conclusions:

  • Deep cavitand-based vesicles represent a novel self-assembled system for molecular recognition and encapsulation.
  • These vesicles offer distinct compartments for simultaneously hosting diverse guest molecules.
  • The findings open avenues for designing advanced host-guest systems with tailored functionalities.