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Updated: May 19, 2026
08:35
Improved Renal Denervation Mitigated Hypertension Induced by Angiotensin II Infusion
Published on: May 26, 2022
Renal denervation therapies for refractory hypertension
Juan F Granada1, Piotr P Buszman
1Skirball Center for Cardiovascular Research for Cardiovascular Research Foundation, 8 Corporate Drive, Orangeburg, NY, USA. jgranada@crf.org
Current Cardiology Reports
|August 14, 2012
Summary
Renal denervation, a minimally invasive procedure, offers a new treatment for severe hypertension. This catheter-based therapy effectively reduces blood pressure and shows potential for other health benefits.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Nephrology
Background:
- Surgical renal denervation was an early, effective but high-risk treatment for severe hypertension.
- Medical therapy replaced surgical denervation due to side effects.
- Advancements in catheter technology have revived interest in renal denervation.
Purpose of the Study:
- To review the anatomical and physiological basis for renal denervation.
- To provide an update on current clinical data for renal denervation in refractory hypertension.
- To discuss emerging technologies in renal denervation.
Main Methods:
- Review of historical data on surgical renal denervation.
- Analysis of recent clinical trial data on radiofrequency renal artery denervation.
- Discussion of technological advancements and future directions in renal denervation.
Main Results:
- Radiofrequency renal artery denervation is safe and effective in small trials for refractory hypertension.
- The procedure significantly reduces blood pressure.
- Potential pleiotropic effects, such as improved glycemic control in diabetics, are being investigated.
Conclusions:
- Renal denervation is a promising therapeutic option for refractory hypertension.
- The procedure is associated with a favorable safety profile.
- Further research and technological innovation are ongoing in this field.
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