State-of-the-Art Review: Transjugular Tricuspid Valve Replacement Using the LuX-Valve Plus System

Severe tricuspid regurgitation remains a major therapeutic challenge, particularly in patients with extensive annular dilation or advanced right heart remodeling. Transcatheter tricuspid valve replacement(TTVR) has emerged as a promising alternative for anatomically complex and high‑risk patients who are not suitable for surgery or transcatheter edge‑to‑edge repair. Among currently available systems, the LuX‑Valve Plus device offers a unique transjugular approach and anchoring strategy. This state‑of‑the‑art review provides a comprehensive overview of the LuX‑Valve Plus system, including technical characteristics, procedural steps, multimodality imaging guidance, and key anatomical considerations for patient selection. Drawing on current literature and expert experience, the review describes a step‑by‑step procedural framework with a focus on anatomical screening, computed tomography-based planning, intraprocedural three‑dimensional transesophageal echocardiography, and the use of advanced imaging modalities such as fusion imaging. Practical tips are provided to optimize device positioning, septal anchoring, and leaflet interaction in the setting of highly variable anatomy. Overall, the LuX‑Valve Plus system broadens the spectrum of TTVR to anatomically challenging patients, and this review offers a practical guide for clinicians by offering detailed technical insights, imaging protocols, and procedural strategies essential for successful implantation and avoidance of complications.