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Updated: May 19, 2026

Murine Model of Intestinal Ischemia-reperfusion Injury
Published on: May 11, 2016
Naturally occurring autoantibodies mediate ischemia/reperfusion-induced tissue injury
1Division of Biology, Kansas State University, Manhattan, Kansas, USA. sdflemin@ksu.edu
Abstract:
Ischemia and reperfusion events within the heart and brain and similar trauma-induced ischemia/reperfusion events lead to significant morbidity and mortality. In the past two decades, an excessive innate immune response has been identified as the mediator of reperfusion-induced tissue damage. Recent evidence indicates that naturally occurring autoantibody (NAb) activation of complement is a major mechanism of injury due to ischemia/reperfusion. This chapter focuses on the antigens exposed by ischemia and recognized by NAbs, the mechanism of complement activation by damaging NAbs and the protective role of IVIG in ischemia/reperfusion-induced pathology.
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