Carcinogenic effects of N-nitroso-3-(substituted phenylimino)-indolin-2-one derivatives
Murali Kumarasamy1, Panneerselvam Theivendren, Rousso Govindarajan
1Department of Chemical Engineering, University of Rovira i Virgili, 26, Av. Paisos Catalans, Tarragona, Spain.
Aim:
A novel series of N-nitroso-3-(substituted phenylimino)-indolin-2-one 3a-h was synthesized and tested for carcinogenic effects.
Materials And Methods:
The synthesized pyrazole derivatives' chemical structures were proved by means of their infra red (IR), proton nuclear magnetic resonance ((1)H-NMR), and mass,and confirmed by elemental analyses. The carcinogenic activity was assessed by 3-(4,5dimethyl thiazole-2yl)-2,5-diphenyltetrazoliumbromide (MTT) cell-viability assay.
Results:
The results show that most of the synthesized compounds exhibit significant carcinogenic activities. Among the synthesized compounds, N-nitroso-3-(2,4-dinitrophenylimino)-indolin-2-one 3h exhibited the most potent carcinogenic activity.
Conclusion:
The structure-activity relationship (SAR) studies show that the nature as well as the position of the amine are important for deciding the activity profile of the indolin-2-one derivatives, which reiterates the need for further experimental investigations.
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