Predicting coupling specificity of GPCRs based on the optimization of the coupling regions
Ran Tao1, Zhenran Jiang, Weiming Yu
1Department of Computer Science & Technology, East China Normal University, Shanghai, China.
Abstract:
Prediction of promiscuous coupling between G-protein coupling receptors (GPCRs) and various G-proteins is one of the challenges for current research. In this article, a novel method that based on the optimization of the coupling regions is proposed. The cross validation results demonstrate that it can achieve an average accuracy of over 80% for promiscuous coupling prediction. The results further suggest that the optimized coupling regions may be important for the processes of signal transduction pathways.
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