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Updated: May 19, 2026
10:46
A Flow Cytometry-Based Cell Surface Protein Binding Assay for Assessing Selectivity and Specificity of an Anticancer Aptamer
Published on: September 13, 2022
Development and characterization of an aptamer binding ligand of fractalkine using domain targeted SELEX
Brett Waybrant1, Timothy R Pearce, Ping Wang
1Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, MN 55455, USA.
Chemical Communications (Cambridge, England)
|September 1, 2012
Abstract:
Fractalkine (FKN) is a unique cell surface protein with potential as a therapeutic target because of its role in inflammatory diseases and cancer. We developed an aptamer, named FKN-S2, with a dissociation constant of 3.4 ± 0.7 nM that is specific to the chemokine domain of fractalkine.
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