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Updated: May 18, 2026
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Establishing Organoids from Human Tooth as a Powerful Tool Toward Mechanistic Research and Regenerative Therapy
Published on: April 13, 2022
Stem cells in the face: tooth regeneration and beyond
Jeremy J Mao1, Pamela G Robey, Darwin J Prockop
1Center for Craniofacial Regeneration, Columbia University Medical Center, 630 West 168 Street - PH7E, New York, NY 10032, USA. jmao@columbia.edu
Cell Stem Cell
|September 11, 2012
Summary
Orofacial stem cells are key to tissue regeneration but their roles are unclear. Further research into these stem/progenitor cells is vital for developing new regenerative therapies for facial reconstruction.
Area of Science:
- Regenerative Medicine
- Stem Cell Biology
- Craniofacial Development
Background:
- The face is unique to individuals.
- Postnatal orofacial tissues contain rare stem cells.
- Clinical needs for orofacial tissue reconstruction are significant.
Purpose of the Study:
- To analyze the current understanding of orofacial stem/progenitor cells.
- To identify knowledge gaps in this field.
- To highlight future directions for regenerative therapies.
Main Methods:
- Literature review and critical analysis.
- Synthesis of existing research.
- Identification of research priorities.
Main Results:
- The contribution of orofacial stem/progenitor cells to development, pathogenesis, and regeneration is poorly understood.
- Significant gaps exist in our knowledge of these cells.
- Potential therapeutic applications remain largely unexplored.
Conclusions:
- Further investigation into orofacial stem/progenitor cells is crucial.
- Understanding these cells can lead to novel regenerative strategies.
- Targeting orofacial stem cells offers promise for tissue repair and reconstruction.
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