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Published on: April 5, 2017
Design, synthesis and evaluation of small molecule reactive oxygen species generators as selective Mycobacterium
Allimuthu T Dharmaraja1, Mallika Alvala, Dharmarajan Sriram
1Department of Chemistry, Indian Institute of Science Education and Research Pune, Pune 411 008, Maharashtra, India.
Abstract:
Here, we report 5-hydroxy-1,2,3,4,4a,9a-hexahydro-1,4-ethano-9,10-anthraquinone (13), a small molecule generating reactive oxygen species (ROS) in pH 7.4 buffer under ambient aerobic conditions that has selective and potent Mycobacterium tuberculosis growth inhibitory activity.
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