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The Bohr effect before Perutz.

Maurizio Brunori¹

¹Department of Biochemical Sciences, Sapienza-University of Rome, P.le A. Moro, 5-00185 Roma, Italy. maurizio.brunori@uniroma1.it

Biochemistry and Molecular Biology Education : a Bimonthly Publication of the International Union of Biochemistry and Molecular Biology

|September 19, 2012

Summary

This summary is machine-generated.

The Bohr effect in hemoglobin involves oxygen-linked histidine dissociation. A paradigm shift proposed a whole-molecule configuration change, paving the way for allostery concepts.

Area of Science:

Biochemistry
Molecular Biology
Protein Chemistry

Background:

The Bohr effect in hemoglobin was initially linked to histidine imidazole dissociation.
Early hypotheses on hemoglobin structure were limited by scarce chemical and structural data.

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