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Related Concept Videos

Complement System01:27

Complement System

The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a membrane...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Pharmacogenomics: Identification of New Drug Targets01:29

Pharmacogenomics: Identification of New Drug Targets

Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
Therapeutic Drug Monitoring: Overview and Classification01:16

Therapeutic Drug Monitoring: Overview and Classification

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood at designated intervals to ensure the drug concentration stays within a therapeutic range. This monitoring is crucial for optimizing individual dosage regimens, enhancing therapeutic efficacy, and minimizing drug-related toxicity. TDM is vital for drugs with narrow therapeutic windows, significant variability in pharmacokinetics, and a clear correlation between plasma levels and...

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In Vitro Methods for Comparing Target Binding and CDC Induction Between Therapeutic Antibodies: Applications in Biosimilarity Analysis
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Progress and Trends in Complement Therapeutics.

Daniel Ricklin1, John D Lambris

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania, 401 Stellar Chance, 422 Curie Blvd, Philadelphia, PA, 19104-6100, USA, ricklin@upenn.edu.

Advances in Experimental Medicine and Biology
|September 20, 2012
PubMed
Summary
This summary is machine-generated.

Complement-directed drug discovery is rapidly advancing, with new therapies targeting the complement cascade for various diseases. Challenges remain in optimizing target selection, intervention strategies, and drug delivery for effective complement balance.

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Area of Science:

  • Immunology and Pharmacology
  • Biotechnology and Drug Development

Background:

  • The field of complement-directed therapeutics has seen significant growth, fueled by early successes and a deeper understanding of complement's role in disease.
  • Advances in analytical techniques, structural biology, and disease models have spurred innovative approaches to complement intervention.

Purpose of the Study:

  • To review recent advancements and emerging trends in complement-directed drug discovery and development.
  • To highlight key changes shaping the perception of complement-targeted therapies.
  • To illustrate the diversity of therapeutic strategies and complement-related diseases.

Main Methods:

  • Review of current literature on complement-directed drug discovery.
  • Analysis of clinical trial pipelines for complement inhibitors.
  • Case studies of complement-related diseases and therapeutic approaches.

Main Results:

  • A surge in creative therapeutic strategies targeting various points in the complement cascade.
  • Numerous compounds showing promise in clinical trials are advancing through development pipelines.
  • Identification of critical questions regarding target selection, intervention, safety, and delivery.

Conclusions:

  • Diverse and tailored therapeutic strategies are necessary to rebalance complement activity in a wide range of acute and chronic diseases.
  • The field is characterized by creativity and diversity in developing complement-targeted drugs.
  • Ongoing research is crucial to address challenges and optimize complement-based therapies.