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Updated: May 18, 2026

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Clinical-oriented Three-dimensional Gait Analysis Method for Evaluating Gait Disorder
Published on: March 4, 2018
Gait pattern and lower extremity alignment in children with Morquio syndrome
Arjun A Dhawale1, Chris Church, John Henley
1Department of Orthopaedics, Nemours/Alfred I. duPont Hospital for Children, Wilmington, Delaware 19899, USA.
Journal of Pediatric Orthopedics. Part B
|September 27, 2012
Summary
Children with Morquio syndrome (MPS IV) exhibit distinct gait abnormalities, including slower walking speed and altered joint mechanics. This study quanties these differences, providing crucial insights into the condition's physical manifestations.
Area of Science:
- Orthopedics
- Pediatrics
- Genetics
Background:
- Gait abnormalities in children with Morquio syndrome (MPS IV) are not well-documented.
- Understanding these gait patterns is crucial for managing the condition.
Purpose of the Study:
- To describe and quantify the gait characteristics of children with Morquio syndrome (MPS IV).
- To compare the gait of children with MPS IV to normal controls.
Main Methods:
- Retrospective review of nine children with MPS IV and no prior lower extremity surgery.
- Analysis of gait, lower extremity radiographs, and patient charts.
Main Results:
- Children with MPS IV demonstrated significantly slower walking speed, reduced cadence, and shorter stride length compared to normal.
- Increased knee flexion, genu valgus, and external tibial torsion were observed during stance.
- Increased knee varus moment was identified, with a strong correlation between genu valgus measurements from gait analysis and radiographs.
Conclusions:
- Children with Morquio syndrome (MPS IV) exhibit characteristic gait deviations.
- These findings highlight the impact of MPS IV on lower extremity biomechanics and joint alignment.
