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Intraocular lens calcification after keratoplasty.
Irmingard M Neuhann1, Thomas F Neuhann, Jens M Rohrbach
1Ophthalmology Department, Red Cross Hospital, Munich, Germany. dr.i.neuhann@neuhann.de
Cornea
|September 27, 2012
Summary
Intraocular lens (IOL) calcification after keratoplasty is linked to inflammation and air injection, not specific IOL types. This finding aids in understanding and preventing post-keratoplasty IOL complications.
Area of Science:
- Ophthalmology
- Biomaterials Science
- Surgical Pathology
Background:
- Calcification of intraocular lenses (IOLs) can occur after various ocular surgeries.
- Understanding the factors contributing to IOL calcification post-keratoplasty is crucial for patient outcomes.
Purpose of the Study:
- To investigate and report on the occurrence of intraocular lens (IOL) calcification following different types of keratoplasty procedures.
- To identify potential contributing factors and characteristics of IOL calcification after corneal transplantation.
Main Methods:
- Analysis of clinical data from patients who developed calcified IOLs post-keratoplasty.
- Histochemical examination of explanted IOLs using alizarin red and von Kossa staining to detect calcium deposits.
Main Results:
- IOL calcification was observed after Descemet stripping automated endothelial keratoplasty, deep anterior lamellar keratoplasty, and penetrating keratoplasty.
- Calcification occurred in hydrophilic acrylic IOLs, irrespective of polymer source, with a median onset of 6.5 months post-surgery.
- Histochemical analysis confirmed calcium deposits on the superficial optic material, associated with anterior chamber inflammation and air injection during surgery.
Conclusions:
- IOL calcification post-keratoplasty appears multifactorial, not tied to specific IOL models or polymers.
- Inflammation and air injection into the anterior chamber may play a role in mediating the calcification process.
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