Related Experiment Video
Updated: May 18, 2026
11:40
Manipulation of Single Neural Stem Cells and Neurons in Brain Slices using Robotic Microinjection
Published on: January 21, 2021
Cellular-level surgery using nano robots
Bo Song1, Ruiguo Yang, Ning Xi
1Department of Electrical and Computer Engineering, Michigan State University, East Lansing, Michigan 48824, USA.
Journal of Laboratory Automation
|September 28, 2012
Summary
We introduce a novel atomic force microscope (AFM)-based nanorobot for precise cellular surgery. This nanorobot enables advanced imaging, manipulation, drug delivery, and real-time monitoring of living samples.
Area of Science:
- Nanotechnology
- Biophysics
- Microscopy
Background:
- Atomic Force Microscopy (AFM) is crucial for nanoscale imaging and mechanical property analysis.
- Existing AFM techniques have limitations in manipulating and performing surgery on living biological samples at the cellular level.
Purpose of the Study:
- To propose and conceptualize a novel AFM-based nanorobot for advanced applications in cellular-level surgery.
- To integrate multiple functionalities including imaging, manipulation, mechanical characterization, and targeted drug delivery.
Main Methods:
- Development of a versatile nanorobot platform utilizing AFM technology.
- Incorporation of tip functionalization for precise local drug delivery.
- Implementation of a "videolized" visual feedback system for real-time monitoring.
Main Results:
- The proposed nanorobot integrates imaging, manipulation, mechanical property characterization, and tracking capabilities.
- Tip functionalization enables precise local drug delivery for complex nano-surgery on cells and bacteria.
- User-friendly "videolized" feedback allows simultaneous surgery operation and result observation.
Conclusions:
- The AFM-based nanorobot offers a powerful tool for intricate nano-surgery on living samples.
- The system's modular design allows for integration with additional modules for expanded property characterization (e.g., local conductance, capacitance).
- This technology has significant potential for advancing research and applications in cell biology and nanomedicine.
