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Effects of Exposure of Formaldehyde to a Rat Model of Atopic Dermatitis Induced by Neonatal Capsaicin Treatment
Published on: September 27, 2017
Atopic dermatitis: epidemiology and pathogenesis update
Lawrence F Eichenfield1, Charles N Ellis, Anthony J Mancini
1University of California, San Diego School of Medicine, Rady Children's Hospital, San Diego, CA 92123, USA. leichenfield@rchsd.org
Abstract:
The prevalence of atopic dermatitis (AD) has increased markedly in the United States over the past 5 decades, with current reports varying from 10% to 20% prevalence in US children, and new diagnoses are estimated at almost 11% per year. Recent research in AD pathophysiology and pathogenesis has demonstrated that AD is associated with epidermal barrier dysfunction and that mutations in the filaggrin gene are implicated in barrier defects. These discoveries hold promise for future breakthroughs in the diagnosis and management of AD.
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