Related Experiment Video
Updated: May 18, 2026

07:44
In vivo Structural Assessments of Ocular Disease in Rodent Models using Optical Coherence Tomography
Published on: July 24, 2020
Distributed scanning volumetric SDOCT for motion corrected corneal biometry.
Ryan P McNabb1, Francesco Larocca, Sina Farsiu
1Department of Biomedical Engineering, Duke University, 136 Hudson Hall, Box 90281, Durham, NC 27708, USA.
Biomedical Optics Express
|October 2, 2012
Summary
Distributed scanning OCT (DSOCT) minimizes patient motion artifacts in corneal biometry. This new method shows comparable repeatability to existing techniques for measuring corneal curvature and power.
Area of Science:
- Ophthalmology
- Biomedical Optics
- Medical Imaging
Background:
- Patient motion significantly impacts the accuracy of corneal biometry.
- Current spectral domain optical coherence tomography (SDOCT) systems are susceptible to motion-induced artifacts.
Purpose of the Study:
- To introduce and evaluate a novel method, distributed scanning OCT (DSOCT), for reducing motion artifacts in corneal biometry.
- To assess the repeatability and accuracy of DSOCT compared to established methods.
Main Methods:
- A pilot study analyzed the power spectrum of axial eye motion using M-mode SDOCT.
- DSOCT was employed in a preliminary patient study to measure anterior and posterior corneal curvatures and corneal power.
- Measurements were compared against corneal topography and Scheimpflug photography.
Main Results:
- DSOCT effectively reduces the impact of patient motion on corneal biometry.
- Repeatability of anterior and posterior corneal curvature measurements using DSOCT was comparable to existing methods.
- Calculated corneal refractive power using DSOCT demonstrated similar repeatability to topography and Scheimpflug photography.
Conclusions:
- DSOCT is a promising technique for accurate corneal biometry, even in the presence of patient motion.
- The method offers comparable precision to current clinical standards, enhancing diagnostic reliability.
- DSOCT utilizes readily available SDOCT technology, facilitating clinical adoption.
Keywords:
(110.4153) Motion estimation and optical flow(110.4500) Optical coherence tomography(170.4460) Ophthalmic optics and devices
