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Updated: May 18, 2026

Lipopolysaccharide Infusion as a Porcine Endotoxemic Shock Model
Published on: December 8, 2023
Toxic shock syndrome in two dogs
Jennifer E Slovak1, Valerie J Parker, Krysta L Deitz
1Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, USA. jeslovak@iastate.edu
Abstract:
Two young, unrelated, spayed female Labrador retrievers were evaluated for severe, diffuse, generalized erythema and edema of the skin. Both dogs exhibited signs of disseminated intravascular coagulopathy and were euthanized. On postmortem examination, toxic shock syndrome (TSS) was diagnosed based on histopathology and supported by skin cultures. TSS is a rarely reported disease in veterinary medicine and can cause acute and profound clinical signs. Rapid recognition of this disease process and immediate treatment may improve the clinical outcome.
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